null

SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F

InChI Key InChIKey=CLGRAWDGLMENOD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50335231   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Fox Chase Chemical Diversity Center, Inc.

Curated by ChEMBL
LigandPNGBDBM50335231(3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 311nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5B9JPubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Fox Chase Chemical Diversity Center, Inc.

Curated by ChEMBL
LigandPNGBDBM50335231(3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03S5PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Fox Chase Chemical Diversity Center, Inc.

Curated by ChEMBL
LigandPNGBDBM50335231(3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 344nMAssay Description:Inhibition of human JAK1 using poly[Glu:Tyr] (4:1) as substrate in presence of 10 uM [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6988PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Fox Chase Chemical Diversity Center, Inc.

Curated by ChEMBL
LigandPNGBDBM50335231(3-{5-[4-(2-Hydroxy-2-methyl-propionyl)-piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+3nMpH: 7.5 T: 2°CAssay Description:Enzyme assay affinity-purified GST fusions of the active kinase domains (GST-Jak1(866-1154), GST-Jak2(808-1132), GST-Jak3(811-1124) and GST-Tyk2(888-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736PDRPubMed