null

SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2)CC1

InChI Key InChIKey=DXWRIDGYFFSIIY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 433474   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent
LigandPNGBDBM433474(US10562853, Compound 1)copy SMILEScopy InChI
Affinity DataEC50:  10nMAssay Description:Biased agonist activity at Gal4-VP16 transcription factor linked human 5-HT1A receptor expressed in human U2OS cells assessed as induction of beta-ar...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6NZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent
LigandPNGBDBM433474(US10562853, Compound 1)copy SMILEScopy InChI
Affinity DataEC50:  8.10nMAssay Description:Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6NZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent
LigandPNGBDBM433474(US10562853, Compound 1)copy SMILEScopy InChI
Affinity DataEC50:  0.794nMAssay Description:Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in ERK1/2 phosphorylation after 15 mins by Alp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6NZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent
LigandPNGBDBM433474(US10562853, Compound 1)copy SMILEScopy InChI
Affinity DataEC50:  41nMAssay Description:Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in calcium mobilization measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4T9HPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent
LigandPNGBDBM433474(US10562853, Compound 1)copy SMILEScopy InChI
Affinity DataEC50:  63nMAssay Description:Biased agonist activity at human 5-HT1A receptor stably expressed in CHO-K1 cells co-expressing Galpha16/GPCR assessed as increase in calcium mobiliz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6NZTPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent
LigandPNGBDBM433474(US10562853, Compound 1)copy SMILEScopy InChI
Affinity DataEC50:  8.10nMAssay Description:Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4T9HPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent
LigandPNGBDBM433474(US10562853, Compound 1)copy SMILEScopy InChI
Affinity DataEC50:  0.794nMAssay Description:Biased agonist activity at human recombinant 5-HT1A receptor stably expressed in CHO-K1 cells assessed as increase in ERK1/2 phosphorylation levels i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4T9HPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
NEUROLIXIS; UNIVERSITE JAGELLONE

US Patent
LigandPNGBDBM433474(US10562853, Compound 1)copy SMILEScopy InChI
Affinity DataEC50:  10nMAssay Description:Biased agonist activity at Gal4-VP16 transcription factor linked human 5-HT1A receptor expressed in human U2OS cells assessed as stimulation of beta-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4T9HPubMed