null
SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 54 hits for monomerid = 50027084
Affinity DataEC50: 1.90nMAssay Description:Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University of Queensland
Curated by ChEMBL
The University of Queensland
Curated by ChEMBL
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at human MC1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 2.90nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at human MC5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0570nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.270nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 3 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.190nMAssay Description:Activity at mouse MC5R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0600nMAssay Description:Activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.180nMAssay Description:Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Mus musculus)
University of Cergy-Pontoise
Curated by ChEMBL
University of Cergy-Pontoise
Curated by ChEMBL
Affinity DataEC50: 0.0300nMAssay Description:Activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation by CRE/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.350nMAssay Description:Agonist activity at mouse melanocortin-3 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.570nMAssay Description:Agonist activity at mouse melanocortin-5 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Mus musculus)
University of Cergy-Pontoise
Curated by ChEMBL
University of Cergy-Pontoise
Curated by ChEMBL
Affinity DataEC50: 0.220nMAssay Description:Agonist activity at mouse melanocortin-1 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0500nMAssay Description:Agonist activity at mouse melanocortin-4 receptor transfected in HEK293 cells after 6 hrs by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University of Queensland
Curated by ChEMBL
The University of Queensland
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Activity at human MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterMore data for this Ligand-Target Pair
Affinity DataEC50: 5.10nMAssay Description:Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterMore data for this Ligand-Target Pair
Affinity DataEC50: 2.10nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterMore data for this Ligand-Target Pair
Affinity DataEC50: 5.70nMAssay Description:Antagonist activity at human MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counterMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University of Queensland
Curated by ChEMBL
The University of Queensland
Curated by ChEMBL
Affinity DataEC50: 110nMAssay Description:Agonist activity at human MC1 receptor expressed in A375 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence countingMore data for this Ligand-Target Pair
Affinity DataEC50: 8.60nMAssay Description:Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by luminescent enzymatic ...More data for this Ligand-Target Pair
Affinity DataEC50: 34nMAssay Description:Agonist activity at EYFP-fused human MC3R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 34nMAssay Description:Agonist activity at EYFP-fused human MC5R expressed in HEK293 cells after 16 to 20 hrs by CRE-driven reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.204nMAssay Description:Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR...More data for this Ligand-Target Pair
Affinity DataEC50: >0.0316nMAssay Description:Agonist activity at human MC4R expressed in high doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 15 mins by HT...More data for this Ligand-Target Pair
Affinity DataEC50: 0.347nMAssay Description:Agonist activity at human MC4R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR...More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University of Queensland
Curated by ChEMBL
The University of Queensland
Curated by ChEMBL
Affinity DataEC50: >0.0316nMAssay Description:Agonist activity at human MC1R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR...More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University of Queensland
Curated by ChEMBL
The University of Queensland
Curated by ChEMBL
Affinity DataEC50: 1.80nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation measured after 3 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 2.80nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells after 3 mins by cAMP assayMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University of Queensland
Curated by ChEMBL
The University of Queensland
Curated by ChEMBL
Affinity DataEC50: 1nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells after 3 mins by cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.10nMAssay Description:Agonist activity at human MC3R expressed in HEK293 cells after 3 mins by cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells after 3 mins by cAMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.10nMAssay Description:Agonist activity at EYFP-fused human MC4R expressed in HEK293 cells assessed as increase in cAMP accumulation after 30 mins by luminescent enzymatic ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.90nMAssay Description:Agonist activity at human melanocortin 4 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...More data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...More data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University of Queensland
Curated by ChEMBL
The University of Queensland
Curated by ChEMBL
Affinity DataEC50: 1.80nMAssay Description:Agonist activity at human melanocortin 1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...More data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split...More data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Agonist activity at human MC3R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells expressing the GScAMP22F cAMP reporter assessed as effect on cAMP accumulation by cAMP split...More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University of Queensland
Curated by ChEMBL
The University of Queensland
Curated by ChEMBL
Affinity DataEC50: >0.0501nMAssay Description:Agonist activity at human melanocortin receptor 1 expressed in human T-Rex-293 cells assessed as stimulation of intracellular cAMP accumulation incub...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0617nMAssay Description:Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incub...More data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using low doxycycline assessed as stimulation of intracellular c...More data for this Ligand-Target Pair
Affinity DataEC50: >0.0501nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular ...More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University of Queensland
Curated by ChEMBL
The University of Queensland
Curated by ChEMBL