null

SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1

InChI Key InChIKey=HUQJRYMLJBBEDO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 22566   

TargetHistamine H4 receptor(Mus musculus (mouse))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of histamine H4 receptor-mediated chemotaxis in mouse bone marrow cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251K7HPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in CHO-K1 cell membranes measured after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6WZQPubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries BV

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Antagonist activity at H4R in human eosinophils assessed as inhibition of imetit-induced shape change by GAFS assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4W6CPubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries BV

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4W6CPubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries BV

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 221nMAssay Description:Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4W6CPubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries BV

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 199nMAssay Description:Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4W6CPubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries BV

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Antagonist actiivty at human H4R expressed in human U2OS cells assessed as inhibition of [35S]GTPgammaS binding after 30 mins by scintillation proxim...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8PB1PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries BV

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Displacement of [3H]-histamine from recombinant human histamine H4 receptor expressed in CHO-K1 cell membranes measured after 30 mins by microbeta sc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6WZQPubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries BV

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Antagonist activity at recombinant human H4 receptor expressed in CHOK1 cells co-expressing Galpha16/aequorin assessed as inhibition of histamine-ind...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C250Z5PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries BV

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 86nMAssay Description:Inhibition of histamine H4 receptor-mediated chemotaxis in human eosinophilsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251K7HPubMed