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SMILES CN(CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(cc2F)C2CC2)c1C)C(=O)C=C

InChI Key InChIKey=CUABMPOJOBCXJI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 259407   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZK5FMHUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PV6Q9F
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of PIK4CB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of BTK in vitamin D3 differentiated human THP1 cells assessed as inhibition of FCgammaR-induced IL8 production measured after 24 hrs by HT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of BTK in human B cells assessed as reduction in anti-IgM/IL4-stimulated CD69 expression on B cells preincubated for 60 mins followed by a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:Inhibition of BTK in human basophils assessed as reduction in anti-IgE mouse IgG1 antibody Le2-stimulated CD63 expression on basophil preincubated fo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetBile salt export pump(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human ERG by Qpatch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9SKRUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C251FVPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KH0QPQUS Patent