null

SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1

InChI Key InChIKey=ZPXSCAKFGYXMGA-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50005536   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 8.40nMAssay Description:Inhibition of [3H]-dopamine uptake at the dopamine transporter in rat striatal tissueMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5FSRPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibition of dopamine uptake in HEK cells expressing human dopamine transporter (hDAT)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC90R8PubMedDrugBank
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 8.10nMAssay Description:Ability to displace [3H]WIN-35428 from Dopamine Transporter of rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC90R8PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 94nMAssay Description:Inhibition of 5-HT uptake in HEK cells expressing human serotonin transporter (hSERT)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC90R8PubMedDrugBank
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 42.6nMAssay Description:Ability to displace [3H]WIN-35428 from Dopamine Transporter in guinea pig striatal membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC90R8PubMedDrugBank
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMAssay Description:Inhibition of NE uptake in HEK cells expressing human noradrenaline transporter (hNET)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC90R8PubMedDrugBank
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
FAES FARMA S A

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8TMNPubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
FAES FARMA S A

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8TMNPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 234nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QF8V57PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 22.1nMAssay Description:Displacement of [3H]WIN-35428 from human recombinant DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4XQTPubMedDrugBank
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of [3H]WIN-35428 binding to human recombinant DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43V1CPubMedDrugBank
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of [3H]GBR-12935 binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6K0FPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of [3H]GBR-12935 binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6K0FPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Inhibition of [3H]GBR-12935 binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6K0FPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Inhibition of [3H]dopamine uptake at the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6K0FPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of [3H]BTCP binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6K0FPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of [3H]cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6K0FPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Inhibition of recombinant human SERT expressed in HEK293 cell membranes assessed as reduction in [3H]5-HT uptake incubated for 22 mins by micro beta ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60RBZPubMedDrugBank
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human DAT expressed in HEK293 cell membranes assessed as reduction in [3H]-DA uptake incubated for 22 mins by micro beta sc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60RBZPubMedDrugBank
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 0.920nMAssay Description:Inhibition of recombinant human NET expressed in HEK293 cell membranes assessed as reduction in [3H]-norepinephrine uptake incubated for 22 mins by m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60RBZPubMedDrugBank
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 42.6nMAssay Description:Compound was tested for inhibition of [3H]-WIN- 35,428 binding at the dopamine transporter in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5FSRPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
FAES FARMA S A

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 231nMAssay Description:Compound was tested for inhibition of [3H]-5-HT reuptake at Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5FSRPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 22.1nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028RQVPubMedDrugBank
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 8.10nMAssay Description:Ability to displace [3H]-WIN-35,428 from dopamine transporter in rat caudate putamen tissueMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21Z43R6PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 8.10nMAssay Description:Inhibition of [3H]-WIN- 35,428 binding to the dopamine transporter in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5FSRPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 12.9nMAssay Description:Ability to displace [3H]- WIN 35,428 from dopamine transporter on rat striatal membrane.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25Q4VF3PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Inhibition of [3H]WIN-35065-2 binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6K0FPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 42.6nMAssay Description:Ability to displace [3H]- WIN 35,428 from dopamine transporter on guinea pig striatal membrane.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25Q4VF3PubMedDrugBank
TargetSodium-dependent dopamine transporter(MOUSE)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse DAT expressed in HEK293 cells assessed as reduction in [3H]-DA uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60RBZPubMed