null
SMILES CN1CC(c2ccccc2)c2cccc(N)c2C1
InChI Key InChIKey=XXPANQJNYNUNES-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50005548
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of full-length recombinant human DAT expressed in CHOK1 cells assessed as reduction in [3H]dopamine uptake pretreated for 20 mins followed...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of dopamine transporter-mediated [3H]dopamine uptake in Wistar rat striatal synaptosomes by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Lundbeck AIS
Curated by PDSP Ki Database
Lundbeck AIS
Curated by PDSP Ki Database
Affinity DataIC50: 830nMAssay Description:Effect on synaptosomal uptake inhibition of 5-hydroxytryptamine (5-HT)More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamineMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of norepinephrine uptake in synaptosomal preparation fro rat hypothalamus, using [3H]norepinephrineMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Lundbeck AIS
Curated by PDSP Ki Database
Lundbeck AIS
Curated by PDSP Ki Database
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of 5-HT uptake in synaptosomal preparation from rat corpus striatum, using [3H]5-HTMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of [3H]BTCP binding to the dopamine transporter.More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
AstraZeneca
Curated by ChEMBL
AstraZeneca
Curated by ChEMBL
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by electrophysiological assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Effect on synaptosomal uptake inhibition of Dopamine transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of dopamine uptake at dopamine transporter.More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of [3H]dopamine uptake at dopamine transporter.More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of [3H]dopamine uptake at the dopamine transporter.More data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Inhibition of [3H]BTCP binding to the dopamine transporter.More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of [3H]dopamine uptake at the dopamine transporter.More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair