null
SMILES COC(=O)C1C2CCC(CC1c1ccc(I)cc1)N2C
InChI Key InChIKey=SIIICDNNMDMWCI-UHFFFAOYSA-N
PDB links: 2 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50010195
Affinity DataIC50: 36nMAssay Description:Binding potency for Norepinephrine transporter using [3H]NEMore data for this Ligand-Target Pair
Affinity DataIC50: 4.21nMAssay Description:Binding potency for Serotonin transporter using [3H]- paroxetineMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Binding affinity at the Serotonin transporter in rat midbrain by inhibition of 0.5 nM [3H]-paroxetine bindingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Binding affinity at the Dopamine transporter in rat striata by inhibition of 0.5 nM [3H]WIN-35428 bindingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataIC50: 1.26nMAssay Description:Inhibition of [3H]WIN-35428 binding to Dopamine transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of [3H]citalopram binding to the serotonin transporter (5-HT) in monkey caudate-putamen.More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:inhibition of [3H]WIN-35428 binding to the dopamine transporter (DAT) in monkey caudate-putamen.More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Ability to inhibit [3H]citalopram binding to serotonin transporter in cynomolgus monkey striatumMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of [3H]3-beta-(4-fluorophenyl)tropane-2beta-carboxylic acid methyl ester binding to dopamine transporter of cynomolgus monkey striatumMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataIC50: 88nMAssay Description:Compound was tested for binding affinity to dopamine reuptake sites in the tissue homogenates prepared from primate rat striatum using [3H]CFT as rad...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Compound was tested for binding affinity to Serotonin transporter sites in homogenates prepared from rat cortical membranes using [3H]paroxetine as r...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of [3H]citalopram binding to the serotonin transporter (5-HT) in monkey caudate-putamen.More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:inhibition of [3H]WIN-35428 binding to the dopamine transporter (DAT) in monkey caudate-putamen.More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Binding affinity at the Norepinephrine transporter in rat frontal cortex by inhibition of 0.5 nM [3H]nisoxetine bindingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of [3H]WIN-35428 binding to Dopamine transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Binding potency for Norepinephrine transporter using [3H]NEMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Binding potency for Serotonin transporter using [3H]- paroxetineMore data for this Ligand-Target Pair