BindingDB

null

SMILES CC(C)NCC(O)COc1cccc2[nH]ccc12

InChI Key InChIKey=JZQKKSLKJUAGIC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50019443

Bile salt export pump(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL

BDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)copy SMILEScopy InChI

IC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q26Q20JNPubMed

Bile salt export pump(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL

BDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)copy SMILEScopy InChI

IC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed

ATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL

BDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)copy SMILEScopy InChI

IC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed

ATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL

BDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)copy SMILEScopy InChI

IC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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KEGG PC cid PC sid Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed

ATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL

BDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)copy SMILEScopy InChI

IC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

PDB
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Details Article
BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed

Targets 28 ▿
- 5-hydroxytryptamine receptor 1A 18
- 5-hydroxytryptamine receptor 1B 11
- 5-hydroxytryptamine receptor 7 10
- Beta-1 adrenergic receptor 8
- Beta-2 adrenergic receptor 7
- Beta-3 adrenergic receptor 3
- 5-hydroxytryptamine receptor 2C 2
- D(2) dopamine receptor 2
- 5-hydroxytryptamine receptor 2A 2
- Serotonin 2 (5-HT2) receptor 2
- 5-hydroxytryptamine receptor 1D 2
- Bile salt export pump 2
- Sodium-dependent serotonin transporter 1
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 1
- 5-hydroxytryptamine receptor 5B 1
- Alpha-1A adrenergic receptor 1
- 5-hydroxytryptamine receptor 5A 1
- 5-hydroxytryptamine receptor 2C isoform A 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- 5-hydroxytryptamine 1D receptor 1
- ATP-binding cassette sub-family C member 2 1
- D(3) dopamine receptor 1
- 5-hydroxytryptamine receptor 2B 1
- 5-hydroxytryptamine receptor 3A 1
- 5-hydroxytryptamine receptor 1F 1
- 5-hydroxytryptamine receptor 1E 1
- 5-hydroxytryptamine receptor 6 1
- ...
Publications 33 ▿
- Eur J Pharmacol 325: 145-53 (1997) 9
- Neuropharmacology 33: 275-317 (1994) 8
- J Med Chem 54: 6874-87 (2011) 7
- J Med Chem 30: 1-12 (1987) 6
- Bioorg Med Chem Lett 17: 5600-4 (2007) 4
- Toxicol Sci 136: 216-41 (2013) 4
- J Pharmacol Exp Ther 270: 665-74 (1994) 4
- Naunyn Schmiedebergs Arch Pharmacol 369: 151-9 (2004) 3
- Naunyn Schmiedebergs Arch Pharmacol 370: 114-23 (2004) 3
- Proc Natl Acad Sci U S A 89: 3630-4 (1992) 3
- Bioorg Med Chem Lett 9: 3243-8 (1999) 3
- Jpn J Pharmacol 52: 195-200 (1990) 3
- Br J Pharmacol 126: 179-88 (1999) 2
- J Med Chem 40: 4415-9 (1998) 2
- Neuron 11: 449-58 (1993) 2
- Biochem Pharmacol 45: 1003-9 (1993) 2
- J Pharmacol Exp Ther 260: 614-26 (1992) 2
- J Biol Chem 268: 18200-4 (1993) 2
- Br J Pharmacol 115: 107-16 (1995) 2
- EMBO J 11: 4779-86 (1992) 1
- Proc Natl Acad Sci U S A 90: 8547-51 (1993) 1
- Mol Pharmacol 42: 180-5 (1992) 1
- Synapse 38: 438-49 (2000) 1
- J Med Chem 48: 6523-43 (2005) 1
- Br J Pharmacol 122: 126-32 (1997) 1
- Biochem Pharmacol 45: 375-83 (1993) 1
- J Med Chem 39: 126-34 (1996) 1
- Toxicol Sci 118: 485-500 (2010) 1
- Proc Natl Acad Sci U S A 90: 408-12 (1993) 1
- Neuropsychopharmacology 3: 349-60 (1990) 1
- Mol Pharmacol 44: 229-36 (1993) 1
- FEBS Lett 333: 25-31 (1993) 1
- J Biol Chem 268: 23422-6 (1993) 1
Institutions 29 ▿
- [CNS-Pharmacology] 9
- [University of Alberta] 8
- [University of Nottingham] 7
- [TBA, Synaptic Pharmaceutical Corporation] 6
- [TBA, Synaptic Pharmaceutical Corporation] 6
- [Lilly Research Laboratories, Ohio State University, Amgen Inc] 4
- [Lilly Research Laboratories, Ohio State University, Amgen Inc] 4
- [Lilly Research Laboratories, Ohio State University, Amgen Inc] 4
- [Niigata College of Pharmacy, Vernalis Research, Universität Würzburg, Merck] 3
- [Niigata College of Pharmacy, Vernalis Research, Universität Würzburg, Merck] 3
- [Niigata College of Pharmacy, Vernalis Research, Universität Würzburg, Merck] 3
- [Niigata College of Pharmacy, Vernalis Research, Universität Würzburg, Merck] 3
- [National Institute of Neurological Disorders and Stroke, Syntex Discovery Research, CNRS, Monash University, The Scripps Research Institute, University of Texas, University of Canterbury, Medical College of Virginia/Virginia Commonwealth University] 2
- [National Institute of Neurological Disorders and Stroke, Syntex Discovery Research, CNRS, Monash University, The Scripps Research Institute, University of Texas, University of Canterbury, Medical College of Virginia/Virginia Commonwealth University] 2
- [National Institute of Neurological Disorders and Stroke, Syntex Discovery Research, CNRS, Monash University, The Scripps Research Institute, University of Texas, University of Canterbury, Medical College of Virginia/Virginia Commonwealth University] 2
- [National Institute of Neurological Disorders and Stroke, Syntex Discovery Research, CNRS, Monash University, The Scripps Research Institute, University of Texas, University of Canterbury, Medical College of Virginia/Virginia Commonwealth University] 2
- [National Institute of Neurological Disorders and Stroke, Syntex Discovery Research, CNRS, Monash University, The Scripps Research Institute, University of Texas, University of Canterbury, Medical College of Virginia/Virginia Commonwealth University] 2
- [National Institute of Neurological Disorders and Stroke, Syntex Discovery Research, CNRS, Monash University, The Scripps Research Institute, University of Texas, University of Canterbury, Medical College of Virginia/Virginia Commonwealth University] 2
- [National Institute of Neurological Disorders and Stroke, Syntex Discovery Research, CNRS, Monash University, The Scripps Research Institute, University of Texas, University of Canterbury, Medical College of Virginia/Virginia Commonwealth University] 2
- [National Institute of Neurological Disorders and Stroke, Syntex Discovery Research, CNRS, Monash University, The Scripps Research Institute, University of Texas, University of Canterbury, Medical College of Virginia/Virginia Commonwealth University] 2
- [U. 109, University of Heidelberg ZMBH, Organon Laboratories, University of North Texas, Roche Bioscience, Janssen Research Foundation, INSERM U.288, Amgen Inc., Universit£ de Lausanne] 1
- [U. 109, University of Heidelberg ZMBH, Organon Laboratories, University of North Texas, Roche Bioscience, Janssen Research Foundation, INSERM U.288, Amgen Inc., Universit£ de Lausanne] 1
- [U. 109, University of Heidelberg ZMBH, Organon Laboratories, University of North Texas, Roche Bioscience, Janssen Research Foundation, INSERM U.288, Amgen Inc., Universit£ de Lausanne] 1
- [U. 109, University of Heidelberg ZMBH, Organon Laboratories, University of North Texas, Roche Bioscience, Janssen Research Foundation, INSERM U.288, Amgen Inc., Universit£ de Lausanne] 1
- [U. 109, University of Heidelberg ZMBH, Organon Laboratories, University of North Texas, Roche Bioscience, Janssen Research Foundation, INSERM U.288, Amgen Inc., Universit£ de Lausanne] 1
- [U. 109, University of Heidelberg ZMBH, Organon Laboratories, University of North Texas, Roche Bioscience, Janssen Research Foundation, INSERM U.288, Amgen Inc., Universit£ de Lausanne] 1
- [U. 109, University of Heidelberg ZMBH, Organon Laboratories, University of North Texas, Roche Bioscience, Janssen Research Foundation, INSERM U.288, Amgen Inc., Universit£ de Lausanne] 1
- [U. 109, University of Heidelberg ZMBH, Organon Laboratories, University of North Texas, Roche Bioscience, Janssen Research Foundation, INSERM U.288, Amgen Inc., Universit£ de Lausanne] 1
- [U. 109, University of Heidelberg ZMBH, Organon Laboratories, University of North Texas, Roche Bioscience, Janssen Research Foundation, INSERM U.288, Amgen Inc., Universit£ de Lausanne] 1
Affinity: 0.32 to 2.0E+5 nM▿
- Ki 72
- IC50 5
- Kd 7
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1