null
SMILES CC[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1
InChI Key InChIKey=JOLUEKLYBWIOKL-HOCLYGCPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50279425
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alpha-ketoglutarate as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Saint Petersburg State University
Curated by ChEMBL
Saint Petersburg State University
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair