null
SMILES Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(c2)C(F)(F)F)c2c(N)ncnc12
InChI Key InChIKey=SIXVRXARNAVBTC-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50396534
TargetAurora kinase B(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 407nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK2(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.89E+3nMAssay Description:Inhibition of WNK2More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of YES1More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.96E+3nMAssay Description:Inhibition of TRKBMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of AXLMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of TRKAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of MAP4K5More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of NEK4More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of MLK3More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of TRKCMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of IKBKEMore data for this Ligand-Target Pair
TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 696nMAssay Description:Inhibition of PKR assessed as EIF2AK2 phosphorylationMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Inhibition of HRI assessed as EIF2AK1 phosphorylationMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GST-tagged PERK cytoplasmic domain (536 to 1116) (unknown origin) assessed as biotinylated His6-tagged EIF2alpha phosphorylation preinc...More data for this Ligand-Target Pair
TargetCytochrome P450 2C8(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 890nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 1A2(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 5 to 60 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human GST-tagged RIPK1 (1 to 479 residues) incubated for 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
GlaxoSmithKline Research and Development
Curated by ChEMBL
GlaxoSmithKline Research and Development
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylationMore data for this Ligand-Target Pair