BindingDB

null

SMILES CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12

InChI Key InChIKey=GDLIGKIOYRNHDA-UHFFFAOYSA-N

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 77970

Trypanothione reductase(Trypanosoma cruzi)
Alma Mater Studiorum-Bologna University

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 3.80E+3nMMore data for this Ligand-Target Pair

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Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Turku

Curated by PDSP K_i Database

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 20nMAssay Description:Inhibition of uptake of 5-HT in rat brain cortexMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2GT5NQDPubMed

Sodium-dependent serotonin transporter(Homo sapiens (Human))
Emory University

Curated by PDSP K_i Database

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 70nMAssay Description:In vivo inhibition of uptake of 5-HT in human plateletsMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2GT5NQDPubMed DrugBank

Transporter(Rattus norvegicus)
TBA

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 700nMAssay Description:Inhibition of uptake of noradrenaline in rat brain hypothalamusMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/TrEMBL
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BindingDB Entry DOI: 10.7270/Q2GT5NQDPubMed

Sodium-dependent dopamine transporter(Rattus norvegicus (rat))
Institut de Recherches Servier

Curated by PDSP K_i Database

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.00E+3nMAssay Description:Inhibition of uptake of dopamine (DA) rat brain striatumMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2GT5NQDPubMed

Histamine H1 receptor(RAT)
Universidad de Valencia

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 0.200nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair

KEGG
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BindingDB Entry DOI: 10.7270/Q2N0176GPubMed

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Institut de Recherches Servier

Curated by PDSP K_i Database

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 0.0400nMAssay Description:Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2N0176GPubMed

Histamine H2 receptor(Cavia porcellus (domestic guinea pig))
Universidad de Valencia

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 720nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2N0176GPubMed

Sodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.00E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2Z321T8PubMed

Trypanothione reductase(Trypanosoma cruzi)
Alma Mater Studiorum-Bologna University

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.23E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21(DE3) assessed as reduction of oxidized trypanothione prein...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q25Q4XKQPubMed

Solute carrier family 22 member 1(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.93E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q23779MDPubMed

Bile salt export pump(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q26Q20JNPubMed

Bile salt export pump(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 3.74E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2ZP488MPubMed

ATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed

ATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed

Bile salt export pump(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed

ATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed

Trypanothione reductase(Trypanosoma cruzi)
Alma Mater Studiorum-Bologna University

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.52E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21 (DE3) pre-incubated for 30 mins using TS2 substrate in pre...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2R2141MPubMed

Mitochondrial import inner membrane translocase subunit TIM10(Saccharomyces cerevisiae S288c)
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 3.78E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2F18X6WPCBioAssay

Sodium-dependent dopamine transporter(Homo sapiens (Human))
Mayo Clinic Jacksonville

Curated by PDSP K_i Database

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 2.78E+3nMAssay Description:Displacement of [3H]Win35428 from human recombinant DAT over-expressed in CHOK1 cellsMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2B85C2TPubMed

Sodium-dependent noradrenaline transporter(Homo sapiens (Human))
Lilly Research Laboratories

Curated by PDSP K_i Database

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 65nMAssay Description:Displacement of [3H]Nisoxetine from human recombinant NET over-expressed in dog MDCK cellsMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2B85C2TPubMed DrugBank

Voltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))TBA

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 9.00E+3nMMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2R78K6MPubMed

Voltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Jagiellonian University

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 1.16E+4nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2D79D5CPubMed

Trypanothione reductase(Trypanosoma brucei brucei)
Canisius College

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 3.40E+3nMAssay Description:Inhibition of recombinant Trypanosoma brucei brucei strain S427 trypanothione reductase assessed as reduction of trypanothione disulphide by 412 nm a...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q27P9166PubMed

Sodium-dependent serotonin transporter(MOUSE)
TBA

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 70nMAssay Description:Inhibition of 5-HT transporter in NMRI albino mouse brain assessed as [3H]5-HT accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2P270P4PubMed

Sodium-dependent noradrenaline transporter(MOUSE)
TBA

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 900nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2P270P4PubMed

Transporter(Rattus norvegicus)
TBA

Curated by ChEMBL

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 900nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]-Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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BindingDB Entry DOI: 10.7270/Q2BG2N05PubMed

Sodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of Turku

Curated by PDSP K_i Database

BDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)copy SMILEScopy InChI

IC50: 90nMAssay Description:In vitro inhibition of accumulation of [14C]-5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2BG2N05PubMed

Targets 39 ▿
- Sodium-dependent serotonin transporter 14
- Trypanothione reductase 9
- Sodium-dependent dopamine transporter 8
- Sodium-dependent noradrenaline transporter 5
- Alpha-1A adrenergic receptor 4
- 5-hydroxytryptamine receptor 2A 4
- 5-hydroxytryptamine receptor 2C 3
- D(2) dopamine receptor 3
- Norepinephrine transporter 3
- 5-hydroxytryptamine receptor 6 3
- Bile salt export pump 3
- D(3) dopamine receptor 2
- 5-hydroxytryptamine receptor 1A 2
- 5-hydroxytryptamine receptor 3A 2
- Transporter 2
- Solute carrier family 22 member 1 1
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 1
- Voltage-dependent N-type calcium channel subunit alpha-1B 1
- Proteasome subunit alpha type-6 1
- Replicase polyprotein 1ab 1
- Serotonin 2 (5-HT2) receptor 1
- Envelope glycoprotein 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- Alpha-2C adrenergic receptor 1
- ATP-binding cassette sub-family C member 2 1
- Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor 1
- Histamine H1 receptor 1
- Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor 1
- Orf1a protein 1
- 5-hydroxytryptamine receptor 1B 1
- Mitochondrial import inner membrane translocase subunit TIM10 1
- D(1A) dopamine receptor 1
- Voltage-dependent L-type calcium channel subunit alpha-1C 1
- 5-hydroxytryptamine receptor 7 1
- 5-hydroxytryptamine receptor 1D 1
- Sodium channel protein type 1/2/3 subunit alpha 1
- Alpha-2A adrenergic receptor 1
- Histamine H2 receptor 1
- ...
Publications 37 ▿
- J Pharmacol Exp Ther 298: 565-80 (2001) 18
- NIDA Res Monogr 178: 440-66 (1998) 7
- J Med Chem 30: 1433-54 (1987) 5
- Toxicol Sci 136: 216-41 (2013) 4
- J Pharmacol Exp Ther 247: 1032-8 (1988) 4
- J Med Chem 23: 1306-10 (1981) 4
- J Pharmacol Exp Ther 226: 686-700 (1983) 3
- Psychopharmacology (Berl) 126: 234-40 (1996) 3
- Eur J Pharmacol 340: 249-58 (1997) 3
- J Med Chem 42: 3154-62 (1999) 3
- J Med Chem 24: 1499-507 (1982) 2
- Med Res Rev (2020) 2
- Neuropharmacology 45: 935-44 (2003) 2
- Bioorg Med Chem 23: 996-1010 (2015) 2
- Neuropharmacology 32: 737-43 (1993) 2
- J Pharmacol Exp Ther 283: 1305-22 (1997) 2
- J Med Chem 21: 78-82 (1978) 2
- Bioorg Med Chem Lett 23: 5515-8 (2013) 2
- Eur J Med Chem 71: 282-9 (2014) 1
- Proc Natl Acad Sci U S A 90: 8547-51 (1993) 1
- ACS Chem Biol 12: 2240-2247 (2017) 1
- Bioorg Med Chem 23: 6528-34 (2015) 1
- Bioorg Med Chem Lett 19: 3031-5 (2009) 1
- Bioorg Med Chem Lett 5: 1957-1960 (1995) 1
- Eur J Med Chem 141: 138-148 (2017) 1
- J Med Chem 61: 4938-4945 (2018) 1
- Drug Metab Dispos 40: 2332-41 (2012) 1
- Neuropharmacology 33: 275-317 (1994) 1
- Toxicol Sci 118: 485-500 (2010) 1
- Bioorg Med Chem 16: 6689-95 (2008) 1
- Eur J Med Chem 140: 187-199 (2017) 1
- J Med Chem 28: 381-8 (1985) 1
- J Med Chem 51: 5932-42 (2008) 1
- J Appl Toxicol 32: 858-66 (2012) 1
- PubChem Bioassay (2010) 1
- Mol Pharmacol 43: 320-7 (1993) 1
- J Med Chem 55: 5704-19 (2012) 1
Institutions 32 ▿
- [Institut de Recherches Servier] 18
- [TBA] 15
- [SRI International] 7
- [McNeil Pharmaceutical, Amgen Inc] 4
- [McNeil Pharmaceutical, Amgen Inc] 4
- [Mayo Clinic Jacksonville, University of Turku, Universidad de Valencia, Pfizer Inc.,] 3
- [Mayo Clinic Jacksonville, University of Turku, Universidad de Valencia, Pfizer Inc.,] 3
- [Mayo Clinic Jacksonville, University of Turku, Universidad de Valencia, Pfizer Inc.,] 3
- [Mayo Clinic Jacksonville, University of Turku, Universidad de Valencia, Pfizer Inc.,] 3
- [Lilly Research Laboratories, Sogang University, University of Bonn, Emory University, Canisius College, Boots Pharmaceuticals] 2
- [Lilly Research Laboratories, Sogang University, University of Bonn, Emory University, Canisius College, Boots Pharmaceuticals] 2
- [Lilly Research Laboratories, Sogang University, University of Bonn, Emory University, Canisius College, Boots Pharmaceuticals] 2
- [Lilly Research Laboratories, Sogang University, University of Bonn, Emory University, Canisius College, Boots Pharmaceuticals] 2
- [Lilly Research Laboratories, Sogang University, University of Bonn, Emory University, Canisius College, Boots Pharmaceuticals] 2
- [Lilly Research Laboratories, Sogang University, University of Bonn, Emory University, Canisius College, Boots Pharmaceuticals] 2
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
- [National Institute of Neurological Disorders and Stroke, University of Alberta, Icahn School of Medicine at Mt. Sinai, Uppsala University, Michigan State University , Pontificia Universidad Catolica del Peru, Jagiellonian University, Alma Mater Studiorum-Bologna University, U. 109, Burnham Center for Chemical Genomics, Universidade Federal de Minas Gerais, University of S£o Paulo, AstraZeneca, University of Oxford, University of Bologna, University of North Carolina at Chapel Hill, Amgen Inc.] 1
Affinity: 0.040 to 1.4E+5 nM▿
- Ki 59
- IC50 28
- Kd 1
- EC50 3
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1