null

SMILES OC(=O)c1cccnc1Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=JZFPYUNJRRFVQU-UHFFFAOYSA-N

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 85507   

TargetTransthyretin(Homo sapiens (Human))
Ume£ University

Curated by ChEMBL
LigandPNGBDBM85507(CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumi...)copy SMILEScopy InChI
Affinity DataKd:  260nMAssay Description:Binding affinity to TTR (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84DP1PubMed
TargetTransthyretin(Homo sapiens (Human))
Ume£ University

Curated by ChEMBL
LigandPNGBDBM85507(CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumi...)copy SMILEScopy InChI
Affinity DataKd:  592nMAssay Description:Dissociation Constants (Kd) associated with the binding of ligands to TTR are expressed in nM. Thermodynamic Binding Parameters associated with ligan...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70J43US Patent
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM85507(CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumi...)copy SMILEScopy InChI
Affinity DataKd:  2.80E+4nMAssay Description:Binding affinity to human His-tagged TEAD4 YBD (217 to 434 residues) expressed in Escherichia coli BL21(DE3) after 30 mins by ITC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22B91H7PubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM85507(CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumi...)copy SMILEScopy InChI
Affinity DataKd:  2.80E+4nMAssay Description:Binding affinity to N-terminal His6-tagged human TEAD4 YAP binding domain (217 to 434 residues) expressed in Escherichia coli C43 (DE3) cells by ITC ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6BC1PubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Universities of Lille

Curated by ChEMBL
LigandPNGBDBM85507(CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumi...)copy SMILEScopy InChI
Affinity DataKd:  2.80E+4nMAssay Description:Binding affinity to His-tagged TEAD4 YPD domain (217 to 434 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titrati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28056GRPubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 85507   

CellTransthyretin(Homo sapiens (Human))TBA
SyringePNGBDBM85507(CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumi...)
ITC DataΔG°: -8.48kcal/mole −TΔS°: 9.54kcal/mole ΔH°: -18.1kcal/mole logk: 1.66E+6
pH: 7.5 T: 25.00°C 
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J67M4JUS Patent