null
SMILES NS(=O)(=O)c1cc(C(O)=O)c(Cl)cc1Cl
InChI Key InChIKey=ZSHHRBYVHTVRFK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 62 hits for monomerid = 13075
Affinity DataIC50: 170nMpH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 400nMAssay Description:The carbonic anhydrase activity was assayed by following the hydration of CO2 according to the method described by Wilbur and Anderson [Wilbur et al....More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMpH: 7.4Assay Description:The carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of the 4-nitrophenylacetate (NPA) to the 4-nitrophenylate...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMpH: 7.4Assay Description:The carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of the 4-nitrophenylacetate (NPA) to the 4-nitrophenylate...More data for this Ligand-Target Pair
Affinity DataIC50: 7.70E+3nMAssay Description:The method for determination of the Ki values is described elsewhere [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; Bülbül et al., J. ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:The method for determination of the Ki values is described elsewhere [Landolfi et al., J. Pharmacol. Toxicol. Methods, 38:169-172; Bülbül et al., J. ...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of hydratase-activity of CA1 from human erythrocytes by CO2-hydration methodMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of hydratase-activity of human erythrocytes CA2 by CO2-hydration methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of esterase-activity of CA1 from human erythrocytes by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of esterase-activity of human erythrocytes CA2 by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of CA1 from human erythrocytes by Lineweaver-Burke analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human erythrocytes CA2 by Lineweaver-Burke analysisMore data for this Ligand-Target Pair
Affinity DataKd: 625nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 12 (30 to 291 residues) expressed in Escherichia coli Rosetta 2 (DE3) strain in presence of ...More data for this Ligand-Target Pair
Affinity DataKd: 1.50E+3nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 4 (19 to 284 residues) expressed in mammalian expression system in presence of ANS by fluore...More data for this Ligand-Target Pair
Affinity DataKd: 2.00E+4nMAssay Description:Binding affinity to recombinant C-terminal His6-tagged full-length human carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) strain in pre...More data for this Ligand-Target Pair
Affinity DataKd: 4.00E+3nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 6 (21 to 290 residues) expressed in Escherichia coli Rosetta 2 (DE3) ...More data for this Ligand-Target Pair
Affinity DataKd: 0.960nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 13 (1 to 262 residues) expressed in Escherichia coli Rosetta 2 (DE3) strain assessed as intr...More data for this Ligand-Target Pair
Affinity DataKd: 0.600nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 9 (38 to 414 residues) expressed in 293-F cells assessed as intrinsic Kd in presence of ANS ...More data for this Ligand-Target Pair
Affinity DataKd: 111nMAssay Description:Binding affinity to recombinant N-terminal His-tagged human carbonic anhydrase 7 (3 to 264 residues) expressed in Escherichia coli BL21 (DE3) strain ...More data for this Ligand-Target Pair
Affinity DataKd: 5.00E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli in presence of ANS by fluorescent thermal shift assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.90nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3)...More data for this Ligand-Target Pair
Affinity DataKd: 1.10nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 6 (21 to 290 residues) expressed in Escherichia coli Rosetta 2 (DE3) ...More data for this Ligand-Target Pair
Affinity DataKd: 1.11E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 3 (4 to 260 residues) expressed in Escherichia coli BL21 (DE3) strain in presence of ANS by ...More data for this Ligand-Target Pair
Affinity DataKd: 0.760nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 12 (30 to 291 residues) expressed in Escherichia coli Rosetta 2 (DE3) strain assessed as int...More data for this Ligand-Target Pair
Affinity DataKd: 2.50E+3nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 5B (40 to 317 residues) expressed in Escherichia coli Rosetta 2 (DE3)...More data for this Ligand-Target Pair
Affinity DataKd: 0.540nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 14 (20 to 280 residues) expressed in Escherichia coli Rosetta2 (DE3) ...More data for this Ligand-Target Pair
Affinity DataKd: 667nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 9 (38 to 414 residues) expressed in 293-F cells in presence of ANS by fluorescent thermal sh...More data for this Ligand-Target Pair
Affinity DataKd: 333nMAssay Description:Binding affinity to recombinant full-length human carbonic anhydrase 2 expressed in Escherichia coli in presence of ANS by fluorescent thermal shift ...More data for this Ligand-Target Pair
Affinity DataKd: 0.140nMAssay Description:Binding affinity to recombinant N-terminal His-tagged human carbonic anhydrase 7 (3 to 264 residues) expressed in Escherichia coli BL21 (DE3) strain ...More data for this Ligand-Target Pair
Affinity DataKd: 442nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human carbonic anhydrase 14 (20 to 280 residues) expressed in Escherichia coli Rosetta2 (DE3) ...More data for this Ligand-Target Pair
Affinity DataKd: 0.470nMAssay Description:Binding affinity to recombinant full-length human carbonic anhydrase 2 expressed in Escherichia coli assessed as intrinsic Kd in presence of ANS by f...More data for this Ligand-Target Pair
Affinity DataKd: 333nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 13 (1 to 262 residues) expressed in Escherichia coli Rosetta 2 (DE3) strain in presence of A...More data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 1 expressed in Escherichia coli assessed as intrinsic Kd in presence of ANS by fluorescent t...More data for this Ligand-Target Pair
Affinity DataKd: 8.40nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 3 (4 to 260 residues) expressed in Escherichia coli BL21 (DE3) strain assessed as intrinsic ...More data for this Ligand-Target Pair
Affinity DataKd: 1.30nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 4 (19 to 284 residues) expressed in mammalian expression system assessed as intrinsic Kd in ...More data for this Ligand-Target Pair
Affinity DataKd: 42nMAssay Description:Binding affinity to recombinant C-terminal His6-tagged full-length human carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) strain assess...More data for this Ligand-Target Pair
Affinity DataKd: 8.40nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 3 expressed in Escherichia coli expression system assessed as kinetic dissociation constant ...More data for this Ligand-Target Pair
Affinity DataKd: 0.780nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 12 expressed in Escherichia coli expression system assessed as kinetic dissociation constant...More data for this Ligand-Target Pair
Affinity DataKd: 1.30nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 4 expressed in Escherichia coli expression system assessed as kinetic dissociation constant ...More data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 7 expressed in Escherichia coli expression system assessed as observed dissociation constant...More data for this Ligand-Target Pair
Affinity DataKd: 630nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 12 expressed in Escherichia coli expression system assessed as observed dissociation constan...More data for this Ligand-Target Pair
Affinity DataKd: 330nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 13 expressed in Escherichia coli expression system assessed as observed dissociation constan...More data for this Ligand-Target Pair
Affinity DataKd: 42nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 5a expressed in Escherichia coli expression system assessed as kinetic dissociation constant...More data for this Ligand-Target Pair
Affinity DataKd: 3.90nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 5b expressed in Escherichia coli expression system assessed as kinetic dissociation constant...More data for this Ligand-Target Pair
Affinity DataKd: 0.950nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 13 expressed in Escherichia coli expression system assessed as kinetic dissociation constant...More data for this Ligand-Target Pair
Affinity DataKd: 330nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 2 expressed in Escherichia coli expression system assessed as observed dissociation constant...More data for this Ligand-Target Pair
Affinity DataKd: 1.10nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 6 expressed in Escherichia coli expression system assessed as kinetic dissociation constant ...More data for this Ligand-Target Pair
Affinity DataKd: 1.10E+4nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 3 expressed in Escherichia coli expression system assessed as observed dissociation constant...More data for this Ligand-Target Pair
Affinity DataKd: 440nMAssay Description:Binding affinity to recombinant human carbonic anhydrase 14 expressed in Escherichia coli expression system assessed as observed dissociation constan...More data for this Ligand-Target Pair