null

SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1

InChI Key InChIKey=SECKRCOLJRRGGV-UHFFFAOYSA-N

PDB links: 5 PDB IDs match this monomer. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 14776   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [531-875](Homo sapiens (Human))
Plexxikon

LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)copy SMILEScopy InChI
Affinity DataIC50: 0.708nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair