null
SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
InChI Key InChIKey=HKSZLNNOFSGOKW-ZGQXJOJZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 96 hits for monomerid = 50059889
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 10 mins by Global fit analysisMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Inhibition of GSK3-beta assessed as NADH level after 10 mins by pyruvate kinase/lactate dehydrogenase coupled spectrophotometric assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Kyung Hee University
Curated by ChEMBL
Kyung Hee University
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of CDK5/p25 (unknown origin)-mediated incorporation of gamma33P into substrate after 20 mins by scintillation counting analysis in presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant Syk (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
TargetProtein kinase C epsilon type(Homo sapiens (Human))
University of California-San Francisco
Curated by ChEMBL
University of California-San Francisco
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human PKCepsilonMore data for this Ligand-Target Pair
TargetProtein kinase C delta type(Homo sapiens (Human))
University of California-San Francisco
Curated by ChEMBL
University of California-San Francisco
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of human PKCdeltaMore data for this Ligand-Target Pair
TargetProtein kinase C gamma type(Homo sapiens (Human))
University of California-San Francisco
Curated by ChEMBL
University of California-San Francisco
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human PKCgammaMore data for this Ligand-Target Pair
TargetProtein kinase C iota type(Homo sapiens (Human))
University of California-San Francisco
Curated by ChEMBL
University of California-San Francisco
Curated by ChEMBL
Affinity DataIC50: 364nMAssay Description:Inhibition of human PKCiotaMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
TargetProtein kinase C beta type(Homo sapiens (Human))
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of PKCbeta2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human SykMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of human ZAP70More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
The University of Tokyo
Curated by ChEMBL
The University of Tokyo
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ASK1 (unknown origin) by fluorescence correlation spectroscopyMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
The University of Tokyo
Curated by ChEMBL
The University of Tokyo
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of ASK1 (unknown origin) by luciferase assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
The University of Tokyo
Curated by ChEMBL
The University of Tokyo
Curated by ChEMBL
Affinity DataKd: 110nMAssay Description:Binding affinity to ASK1 (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK3 expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Kyung Hee University
Curated by ChEMBL
Kyung Hee University
Curated by ChEMBL
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of ROS1 by HotSpot assay relative to controlMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of JAK3 expressed in insect Sf21 cells assessed as inhibition of biotinylated substrate phosphorylationMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant GST-GSK3beta expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
TargetProtein kinase C epsilon type(Homo sapiens (Human))
University of California-San Francisco
Curated by ChEMBL
University of California-San Francisco
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant PKCE expressed in Bac-to Bac baculovirus systemMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Zhejiang University
Curated by ChEMBL
Zhejiang University
Curated by ChEMBL
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of recombinant IKK2 expressed in Bac-to Bac baculovirus systemMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant Aurora A expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Zhejiang University
Curated by ChEMBL
Zhejiang University
Curated by ChEMBL
Affinity DataIC50: 670nMAssay Description:Inhibition of recombinant MEK1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of recombinant ERK1 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of GST-GSK3betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human LynMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Griffith University
Curated by ChEMBL
Griffith University
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of GST-tagged MAPKAPK2 assessed as [33P] incorporation after 40 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
University of Namur
Curated by ChEMBL
University of Namur
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant GST-fused NIK expressed in Sf9 cells after 60 mins by radiometric protein kinase assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
Affinity DataIC50: 4.19E+3nMAssay Description:Inhibition of CK1alpha1More data for this Ligand-Target Pair
Affinity DataIC50: 3.62E+3nMAssay Description:Inhibition of CK2alphaMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Centre Universitaire
Curated by ChEMBL
Centre Universitaire
Curated by ChEMBL
Affinity DataIC50: 3.18E+3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Griffith University
Curated by ChEMBL
Griffith University
Curated by ChEMBL
Affinity DataIC50: 36.3nMAssay Description:Inhibition of MAPKAPK2More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Centre Universitaire
Curated by ChEMBL
Centre Universitaire
Curated by ChEMBL
Affinity DataIC50: 49.0nMAssay Description:Inhibition of TYRO3/SKYMore data for this Ligand-Target Pair
Affinity DataIC50: 5.09E+3nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Institute of Technology and Science
Curated by ChEMBL
Institute of Technology and Science
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of c-Src after 60 minsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Institute of Technology and Science
Curated by ChEMBL
Institute of Technology and Science
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of GST-fussed c-SRC after 30 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 in presence of ATP measured without preincubation by AlphaScreen analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human N-terminal His-tagged phosphorylated VEGFR2 in presence of ATP measured without preincubation by AlphaScreen analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human N-terminal His-tagged phosphorylated VEGFR2 preincubated for 120 mins in presence of ATP by AlphaScreen analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.32E+3nMAssay Description:Inhibition of telomerase in human SW1116 cells after 24 hrs by TRAP-PCR-ELISA assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Carna Biosciences, Inc.
Curated by ChEMBL
Carna Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Inhibition of FLT3 by colorimetric analysisMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Vertex Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of GSK3-beta by colorimetric analysisMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Institute of Technology and Science
Curated by ChEMBL
Institute of Technology and Science
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of His6-tagged c-Src kinase domain using AEEEIYGEFEAKKKK as substrate pre-incubated for 10 mins before substrate addition measured after 3...More data for this Ligand-Target Pair