null
SMILES CN(C)CCc1c[nH]c2cccc(O)c12
InChI Key InChIKey=SPCIYGNTAMCTRO-UHFFFAOYSA-N
PDB links: 2 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 50 hits for monomerid = 50081701
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University
Curated by PDSP Ki Database
Stanford University
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University
Curated by PDSP Ki Database
Stanford University
Curated by PDSP Ki Database
Affinity DataKi: 25nMAssay Description:In vitro binding to 5-hydroxytryptamine 2A receptor using [125 I]-DOIMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University
Curated by PDSP Ki Database
Stanford University
Curated by PDSP Ki Database
Affinity DataKi: 323nMAssay Description:Displacement of [3H]MDL100907 from 5HT2A receptor in Sprague-Dawley rat brain by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University
Curated by PDSP Ki Database
Stanford University
Curated by PDSP Ki Database
Affinity DataKi: 390nMAssay Description:Compound was tested for binding affinity using [3H]-MDL-100,907 at 5-hydroxytryptamine 2A receptor sites in rat cortical homogenate.More data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 7.80nMAssay Description:Modulation of human 5HT2C expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:Modulation of human 5HT2A expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair
Affinity DataIC50: 352nMAssay Description:1. Culture the cells in cell culture medium (DMEM containing 10% FBS 1× penicillin-streptomycin 300 μg/ml G418 and 100 μg/ml hygromycin B) ...More data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:1. Culture the cells in cell culture medium (DMEM containing 10% FBS 1× penicillin-streptomycin 300 μg/ml G418 and 100 μg/ml hygromycin B) ...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2 4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ...More data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+3nMAssay Description:i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2 4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Table 2: i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2 4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followe...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Table 2: i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2 4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followe...More data for this Ligand-Target Pair
Affinity DataEC50: 6.5nMAssay Description:Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
Affinity DataEC50: 75nMAssay Description:Displacement of [3H]-ketanserin from human 5-HT2A receptor incubated for 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 75nMAssay Description:Displacement of [3H]-ketanserin from human 5-HT2A receptor incubated for 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 6.5nMAssay Description:Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
Affinity DataEC50: 9.80nMAssay Description:Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
Affinity DataEC50: 9.90nMAssay Description:Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
Affinity DataEC50: 4.30nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
Affinity DataEC50: 4.30nMAssay Description:Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...More data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determi...More data for this Ligand-Target Pair
Affinity DataEC50: 58nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor de...More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determi...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Stanford University
Curated by PDSP Ki Database
Stanford University
Curated by PDSP Ki Database
Affinity DataEC50: 2.30E+3nMAssay Description:Tested for its ability to activate phospholipase C by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq f...More data for this Ligand-Target Pair