null

SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C#N

InChI Key InChIKey=KFHYZKCRXNRKRC-MRXNPFEDSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 40 hits for monomerid = 50139391   

TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.400nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB46NQPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.447nMAssay Description:Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4V5HPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN07JCPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]N-alpha methyl histamine from human cloned histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z31ZNTPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416WR3PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571CSTPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ33RVPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28S4Q7CPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JZNPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]-N-alpha methyl histamine from human H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M65G0PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8RDTPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from cloned human histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4V5HPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  1.23nMAssay Description:In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8RDTPubMed
TargetHrh3 protein(RAT)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  1.23nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN07JCPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  1.35nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571CSTPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  1.35nMAssay Description:Displacement of [3H]-N-alpha methyl histamine from rat H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M65G0PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  1.35nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ33RVPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from rat cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JZNPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N879GXPubMed
TargetHistamine H3 receptor(GUINEA PIG)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  2.57nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN07JCPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-NAMH from rat histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72JFPPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  3.20nMAssay Description:Binding potency was determined by displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4V5HPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  3.20nMAssay Description:Binding potency was determined by displacement of [3H]N-alpha-methyl histamine from histamine H3 receptor of rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4V5HPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  3.22nMAssay Description:Displacement of [3H]N-alpha methyl histamine from rat cortical membrane histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z31ZNTPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  3.22nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416WR3PubMed
TargetHrh3 protein(RAT)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  3.24nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN07JCPubMed
TargetHistamine receptor H3(Dog)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  3.89nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN07JCPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Displacement of [3H]RAMH from human histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40W49PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  4.57nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN07JCPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  4.57nMAssay Description:Antagonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as inhibition of RAMH-stimulated [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M65G0PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72JFPPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W66MRBPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  31nMAssay Description:Displacement of [3H]NAMH from rat histamine H3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W66MRBPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  400nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JZNPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  1.62E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN07JCPubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi:  6.76E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN07JCPubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SN07JCPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataEC50:  17.4nMAssay Description:Agonist activity at rat histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M65G0PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataEC50:  1.29nMAssay Description:Agonist activity at human histamine H3 receptor expressed in HEK239 cells assessed as reduction of basal [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M65G0PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche Ltd.

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)copy SMILEScopy InChI
Affinity DataIC50: 0.630nMAssay Description:Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8Z60PubMed