null

SMILES Nc1nc(NC2CC2)c2ncn([C@@H]3C[C@H](CO)C=C3)c2n1

InChI Key InChIKey=MCGSCOLBFJQGHM-SCZZXKLOSA-N

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50366816   

TargetAlbumin(Homo sapiens (Human))
Mercer University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50366816(ABACAVIR | Epzicom | Ziagen)copy SMILEScopy InChI
Affinity DataKd:  4.40E+4nMAssay Description:Binding affinity to human serum albumin with excitation at 280 nm after 2 hrs by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N82W0PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
The University of Georgia

Curated by ChEMBL
LigandPNGBDBM50366816(ABACAVIR | Epzicom | Ziagen)copy SMILEScopy InChI
Affinity DataEC50:  1.55E+4nMAssay Description:In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutantMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2639Q86PubMedDrugBank
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
The University of Georgia

Curated by ChEMBL
LigandPNGBDBM50366816(ABACAVIR | Epzicom | Ziagen)copy SMILEScopy InChI
Affinity DataEC50:  5.30E+3nMAssay Description:In vitro antiviral activity against HIV-1 Reverse transcriptase wild typeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2639Q86PubMedDrugBank
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50366816(ABACAVIR | Epzicom | Ziagen)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of P-gp overexpressed in human 12D7-MDR cells assessed as inhibition of NBD-Aba efflux after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ35MWPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50366816(ABACAVIR | Epzicom | Ziagen)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of P-gp overexpressed in human 12D7-MDR cells assessed as inhibition of calcein-AM efflux after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ35MWPubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Gilead Science, Inc

Curated by ChEMBL
LigandPNGBDBM50366816(ABACAVIR | Epzicom | Ziagen)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition on HIV1 reverse transcriptase p66/p51More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z4774PubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)TBA
LigandPNGBDBM50366816(ABACAVIR | Epzicom | Ziagen)copy SMILEScopy InChI
Affinity DataIC50: 2.47E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1069FPubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50366816(ABACAVIR | Epzicom | Ziagen)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1069FPubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50366816(ABACAVIR | Epzicom | Ziagen)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of P-gp in human CMEC/D3 cells assessed as inhibition of NBD-Aba efflux after 30 mins by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ35MWPubMed