null
SMILES Nc1nc(NC2CC2)c2ncn([C@@H]3C[C@H](CO)C=C3)c2n1
InChI Key InChIKey=MCGSCOLBFJQGHM-SCZZXKLOSA-N
PDB links: 4 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50366816
Affinity DataKd: 4.40E+4nMAssay Description:Binding affinity to human serum albumin with excitation at 280 nm after 2 hrs by spectrofluorimetric analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
The University of Georgia
Curated by ChEMBL
The University of Georgia
Curated by ChEMBL
Affinity DataEC50: 1.55E+4nMAssay Description:In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutantMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
The University of Georgia
Curated by ChEMBL
The University of Georgia
Curated by ChEMBL
Affinity DataEC50: 5.30E+3nMAssay Description:In vitro antiviral activity against HIV-1 Reverse transcriptase wild typeMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of P-gp overexpressed in human 12D7-MDR cells assessed as inhibition of NBD-Aba efflux after 30 mins by flow cytometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of P-gp overexpressed in human 12D7-MDR cells assessed as inhibition of calcein-AM efflux after 30 mins by flow cytometryMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition on HIV1 reverse transcriptase p66/p51More data for this Ligand-Target Pair
Affinity DataIC50: 2.47E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of P-gp in human CMEC/D3 cells assessed as inhibition of NBD-Aba efflux after 30 mins by flow cytometryMore data for this Ligand-Target Pair