null
SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl
InChI Key InChIKey=OTBXOEAOVRKTNQ-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50000334
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysisMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 1.05E+3nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of cGMP hydrolysis by human platelet phosphodiesteraseMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research
Curated by ChEMBL
Syntex Research
Curated by ChEMBL
Affinity DataIC50: 82nMAssay Description:Inhibition of human blood platelet c-AMP phosphodiesteraseMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research
Curated by ChEMBL
Syntex Research
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research
Curated by ChEMBL
Syntex Research
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of hydrolysis of c-AMP phosphodiesterase in human plateletsMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataEC50: 1.05E+3nMAssay Description:Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research
Curated by ChEMBL
Syntex Research
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research
Curated by ChEMBL
Syntex Research
Curated by ChEMBL
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In DepthDetails
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research
Curated by ChEMBL
Syntex Research
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of platelet cAMP phosphodiesteraseMore data for this Ligand-Target Pair