null

SMILES Clc1ccc2N=C3NC(=O)CN3Cc2c1Cl

InChI Key InChIKey=OTBXOEAOVRKTNQ-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50000334   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysisMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2513X52PubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataEC50:  1.05E+3nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2513X52PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of cGMP hydrolysis by human platelet phosphodiesteraseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20P0Z03PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataIC50: 82nMAssay Description:Inhibition of human blood platelet c-AMP phosphodiesteraseMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
In DepthDetails
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of hydrolysis of c-AMP phosphodiesterase in human plateletsMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataEC50:  1.05E+3nMAssay Description:Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2513X52PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
In DepthDetails
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of platelet cAMP phosphodiesteraseMore data for this Ligand-Target Pair