null
SMILES CN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cccc(N3CCn4c5CCCCc5cc4C3=O)c2CO)nc1
InChI Key InChIKey=USAWUCOOXSXRMR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 111945
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut, Inc.; Genentech, Inc.
US Patent
Gilead Connecticut, Inc.; Genentech, Inc.
US Patent
Affinity DataIC50: 5nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut, Inc.; Genentech, Inc.
US Patent
Gilead Connecticut, Inc.; Genentech, Inc.
US Patent
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human full length His-tagged BTK expressed in baculovirus expression system by Z-LYTE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Gilead Connecticut, Inc.; Genentech, Inc.
US Patent
Gilead Connecticut, Inc.; Genentech, Inc.
US Patent
Affinity DataIC50: 45nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of BCR-induced CD69 expression on B cells prein...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Mus musculus)
Genentech, Inc., Research and Early Development, 1 DNA Way, South San Francisco, California 94080, United States.
Curated by ChEMBL
Genentech, Inc., Research and Early Development, 1 DNA Way, South San Francisco, California 94080, United States.
Curated by ChEMBL
Affinity DataIC50: 107nMAssay Description:Inhibition of BTK in goat F(ab')2anti-mouse IgM-stimulated Balb/c mouse splenocyte B cells assessed as suppression of BCR-mediated CD86 induction pre...More data for this Ligand-Target Pair