null

SMILES ONC(=O)CN(Cc1ccccc1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F

InChI Key InChIKey=HNXQLWUITFQYPE-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 11330   

TargetNeutrophil collagenase(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataKi:  1.10nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571DBDPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571DBDPubMed
TargetCollagenase ColG(Clostridium histolyticum)
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataKi:  36nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataKi:  42nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataKi:  90nM ΔG°:  -9.61kcal/molepH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11330(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571DBDPubMed