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SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccccc1

InChI Key InChIKey=QCLOBJCDRHHNCL-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 11331   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571DBDPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetCollagenase ColG(Clostridium histolyticum)
Universita degli Studi

LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi:  27nMAssay Description:The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi:  31nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi:  42nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571DBDPubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi:  42nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi:  60nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetStromelysin-1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi:  70nM ΔG°:  -10.1kcal/molepH: 7.5 T: 2°CAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MW2FC7PubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi:  120nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
Universita degli Studi

LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi:  145nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataKi: >200nM ΔG°: >-9.13kcal/molepH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736P45PubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita degli Studi

LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571DBDPubMed
TargetGelatinase()TBA
LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataIC50: 204nMMore data for this Ligand-Target Pair
In DepthDetails
TargetBone morphogenetic protein 1(Homo sapiens (Human))
FibroGen Inc.

Curated by ChEMBL
LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PCP after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22808SMPubMed
TargetMeprin A subunit beta(Homo sapiens)
Fraunhofer Institute for Cell Therapy and Immunology IZI

Curated by ChEMBL
LigandPNGBDBM11331(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)copy SMILEScopy InChI
Affinity DataIC50: 4.05E+4nMAssay Description:Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5WH0PubMed