null

SMILES COC(=O)c1c(O)cccc1OCCCCNC(=O)[C@H](Cc1ccc(OCC(O)=O)cc1)NC(=O)OC(C)(C)C

InChI Key InChIKey=IKOXRHVKSOJWLA-FQEVSTJZSA-N

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 13986   

TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM13986(2-{4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-({4-...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of T-cell Protein Tyrosine Phosphatase (TCPTP)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B30QVPubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM13986(2-{4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-({4-...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+5nM ΔG°: >-4.99kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PXBPubMed
LigandPNGBDBM13986(2-{4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-({4-...)copy SMILEScopy InChI
Affinity DataKi:  2.19E+5nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8VRJ
LigandPNGBDBM13986(2-{4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-({4-...)copy SMILEScopy InChI
Affinity DataKi:  2.20E+5nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8VRJ
LigandPNGBDBM13986(2-{4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-({4-...)copy SMILEScopy InChI
Affinity DataKi:  2.20E+5nMAssay Description:Inhibition of Protein-tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B30QVPubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM13986(2-{4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-({4-...)copy SMILEScopy InChI
Affinity DataKi:  2.20E+5nM ΔG°:  -4.94kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3PXBPubMed