null
SMILES CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(OC)c2)nc1NC1CCOCC1
InChI Key InChIKey=GYQYAJJFPNQOOW-UHFFFAOYSA-N
PDB links: 2 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 42 hits for monomerid = 144315
Affinity DataKi: 2nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using Glu/Tyr peptide substrate incubated for 120 mins measured after 40 mins incubation under dark by...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of wild type FLT3 (unknown origin) using Glu/Tyr peptide substrate incubated for 120 mins measured after 40 mins incubation under dark by ...More data for this Ligand-Target Pair
Affinity DataKi: 1.49E+3nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by...More data for this Ligand-Target Pair
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))TBA
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of CDK7/cyclin H/MAT1 (unknown origin) using HYSPTSPSYSPTSPSYSPTSPSKKKK-O substrate incubated for 120 mins measured after 40 mins incubati...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) using histone 1 protein substrate incubated for 120 mins measured after 40 mins incubation under dark by...More data for this Ligand-Target Pair
Affinity DataIC50: 6.76E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 (564 to 993 residues) cytoplasmic domain expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 0.730nMAssay Description:Inhibition of N-terminal GST-tagged human AXL (464 to 885 residues) cytoplasmic domain expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
TargetTranscription factor ETV6/Tyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Shanghai University
Curated by ChEMBL
Shanghai University
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of TEL/AXL (unknown origin) expressed in mouse BA/F3 cells assessed as growth inhibition after 72 hrs by SRB assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of AXL (unknown origin) using poly (Glu, Tyr) as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.290nMAssay Description:Inhibition of FLT3 expressed in human SEMK2 cells assessed as reduction in FLT3 phosphorylation incubated for 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of AXL (unknown origin) using poly [Glu, Tyr] 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of FLT3 (unknown origin) using MBP as substrate incubated for 40 mins in presence of ATP by ADP-Glo assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 7.46nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 7.35nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 7.01nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 6.62nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 5.87nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 5.33nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 5.15nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 6.24nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:The test compounds were dissolved in DMSO, and subjected to a 3-fold serial gradient dilution for 10 times. AXL kinase was transferred with different...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 0.290nMAssay Description:Blocking activity against Beta-2 adrenergic receptor in guinea pig tracheal stripsMore data for this Ligand-Target Pair
Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:A partial protein of only a kinase domain of FLT3 protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Examp...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.
US Patent
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.
US Patent
Affinity DataIC50: 1.90nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital
Curated by ChEMBL
Affinity DataIC50: 0.730nMAssay Description:Binding affinity towards rat beta adrenergic receptor from heart membranes.More data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase receptor(Homo sapiens (Human))
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.
US Patent
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.
US Patent
Affinity DataIC50: 1.5nMAssay Description:A recombinant retrovirus was created from expression plasmid FLAG-EML4-ALKv1/pMX-iresCD8 in which cDNA for EMLA-ALK fusion protein v1 was integrated,...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.
US Patent
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.
US Patent
Affinity DataIC50: 3.40nMAssay Description:A partial protein of only a kinase domain of RET protein was purchased from Carna Biosciences Inc., Japan. The phosphorylation activity toward a pept...More data for this Ligand-Target Pair