null

SMILES COC(=O)[C@@H]1CN(CCN1C(C)=O)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1

InChI Key InChIKey=FJEBNLPKFAZSEO-QHCPKHFHSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 149446   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research, Inc.

US Patent
LigandPNGBDBM149446(US10434101, Compound I-48 | US11096942, Compound I...)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.5Assay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2DVSUS Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research, Inc.

US Patent
LigandPNGBDBM149446(US10434101, Compound I-48 | US11096942, Compound I...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.5Assay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2DVSUS Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))TBA
LigandPNGBDBM149446(US10434101, Compound I-48 | US11096942, Compound I...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GT5RBQUS Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))TBA
LigandPNGBDBM149446(US10434101, Compound I-48 | US11096942, Compound I...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3HD3US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research, Inc.

US Patent
LigandPNGBDBM149446(US10434101, Compound I-48 | US11096942, Compound I...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GT5RBQUS Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research, Inc.

US Patent
LigandPNGBDBM149446(US10434101, Compound I-48 | US11096942, Compound I...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NK3HD3US Patent