null

SMILES Fc1ccccc1NC(=O)c1ccc2ccccc2c1

InChI Key InChIKey=BYCMCIFIKZHIRR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 15348   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15348(ChemBridge compound no. 3 | N-(2-fluorophenyl)naph...)copy SMILEScopy InChI
Affinity DataIC50: 470nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395](Homo sapiens (Human))
University of Texas Southwestern Medical Center

LigandPNGBDBM15348(ChemBridge compound no. 3 | N-(2-fluorophenyl)naph...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+4nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))TBA
LigandPNGBDBM15348(ChemBridge compound no. 3 | N-(2-fluorophenyl)naph...)copy SMILEScopy InChI
Affinity DataIC50: 251nMAssay Description:Inhibition of Plasmodium falciparum HIs6-tagged DHODH expressed in Escherichia coli DH5alpha using L-dihydroorotate as substrate by DCIP-based spectr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ13W3
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [H185A](Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15348(ChemBridge compound no. 3 | N-(2-fluorophenyl)naph...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [R265A](Plasmodium falciparum)
University of Texas Southwestern Medical Center

LigandPNGBDBM15348(ChemBridge compound no. 3 | N-(2-fluorophenyl)naph...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed