null

SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Oc2ccc(cc2)[N+]([O-])=O)n1

InChI Key InChIKey=GYXIFIORIDAIKZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 153718   

TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Technical University of Dortmund

LigandBDBM153718(N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)copy SMILEScopy InChI

Affinity DataIC50: 60nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2NRBPubMed

TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))TBA

LigandBDBM153718(N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)copy SMILEScopy InChI

Affinity DataIC50: 146nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails

TargetEpidermal growth factor receptor(Homo sapiens (Human))
TU Dortmund University

Curated by ChEMBL

LigandBDBM153718(N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-...)copy SMILEScopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1G59PubMed