null

SMILES FC(F)(F)S(=O)(=O)c1cc(ccc1N[C@H](CCN1CCOCC1)CSc1ccccc1)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@H](C#N)c1ccccc1-c1ccc(Cl)cc1

InChI Key InChIKey=VSTRECJFPCMULL-RQSCIUFGSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 156396   

TargetBcl-2-like protein 1(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM156396(US9018381, 19 | US9248140, 19)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BC3X8DUS Patent
TargetApoptosis regulator Bcl-2 [1-204](Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM156396(US9018381, 19 | US9248140, 19)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMpH: 7.5Assay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-c) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21G0K34US Patent
TargetBcl-2-like protein 1 [1-209](Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM156396(US9018381, 19 | US9248140, 19)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 7.5Assay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-c) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21G0K34US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM156396(US9018381, 19 | US9248140, 19)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BC3X8DUS Patent