null

SMILES CCOc1nc(NC(=O)Cc2ccccc2)cc(N)c1C#N

InChI Key InChIKey=MPULMLDKNWNYOT-UHFFFAOYSA-N

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 15926   

TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15926(Aminopyridine-Based Inhibitor 6e | N-(4-Amino-5-cy...)copy SMILEScopy InChI
Affinity DataIC50: 570nMpH: 7.2 T: 2°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26WDXPubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15926(Aminopyridine-Based Inhibitor 6e | N-(4-Amino-5-cy...)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of JNK1-mediated ATF2 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0PZWPubMed
Target40S ribosomal protein S27(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM15926(Aminopyridine-Based Inhibitor 6e | N-(4-Amino-5-cy...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of Mps1-mediated p38 MAPK phosphorylation after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0PZWPubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15926(Aminopyridine-Based Inhibitor 6e | N-(4-Amino-5-cy...)copy SMILEScopy InChI
Affinity DataIC50: 770nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P26WDXPubMed