null

SMILES NC1=NC(=O)C(N1)=C1CCNC(=O)c2[nH]ccc12

InChI Key InChIKey=JYRJOQGKGMHTOO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 16591   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataKi:  659nM ΔG°:  -8.57kcal/molepH: 7.5 T: 2°CAssay Description:For Ki determinations a matrix of inhibitor and substrate concentrations were tested. Inhibitor concentrations were tested from four times IC50 with ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 266nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 856nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 168nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 8.83E+3nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 190nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed
LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 420nMpH: 7.5 T: 2°CAssay Description:NSC 109555 was diluted in water. All other drugs were dissolved in DMSO, in which case the final DMSO concentration in reactions was 10%, and the con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67F9QPubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 112nMpH: 7.2Assay Description:In vitro kinase assay using SPA assay kit from Amersham Pharmacia Biotech, Uk.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN14M9PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 250nMpH: 7.2Assay Description:In vitro kinase assay using SPA assay kit from Amersham Pharmacia Biotech, Uk.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN14M9PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 111nMpH: 7.2Assay Description:In vitro kinase assay using SPA assay kit from Amersham Pharmacia Biotech, Uk.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN14M9PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 725nMAssay Description:In vitro inhibitory concentration against checkpoint kinase 1 (Chk1) by using [gamma-33P]-ATP] as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP45MVPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN66MHPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 824nMAssay Description:In vitro inhibitory concentration against human mitogen-activated protein kinase-1 (MEK-1) by using [gamma-33P]-ATP] as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP45MVPubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 183nMAssay Description:In vitro inhibitory concentration against checkpoint kinase 2 (Chk2) by using [gamma-33P]-ATP] as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP45MVPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vernalis (R&D) Ltd

LigandPNGBDBM16591((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 353nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor compound in the presence ATP/[gamma-33P] ATP. 33P ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2154F9KPubMed