null

SMILES CCc1nc(C(N)=O)c(Nc2ccc(cc2)N2CCC(CC2)N2CCN(C)CC2)nc1O[C@@H]1CCN(C1)C(=O)C=C

InChI Key InChIKey=QKDCLUARMDUUKN-XMMPIXPASA-N

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 170514   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astellas Pharma Inc.

US Patent
LigandPNGBDBM170514(US9085540, 54)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:The phosphorylation activity on the peptide substrate of EGFR was investigated using LabChip (trademark) Systems (Caliper Life Sciences, Inc.). For t...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astellas Pharma Inc.

US Patent
LigandPNGBDBM170514(US9085540, 54)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:The phosphorylation activity on the peptide substrate of EGFR was investigated using LabChip (trademark) Systems (Caliper Life Sciences, Inc.). For t...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astellas Pharma Inc.

US Patent
LigandPNGBDBM170514(US9085540, 54)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of wild type EGFR in human NCI-H1666 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR Del ex19 mutant in human PC9 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR Del ex19/T790M double mutant in human PC9 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM170514(US9085540, 54)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR Del ex19 mutant in human HCC827 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair