null

SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C

InChI Key InChIKey=XYFPWWZEPKGCCK-UHFFFAOYSA-N

PDB links: 7 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 1773   

TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataKi:  14nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8C3GUS Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataKi:  97nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8C3GUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis

LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:With regard to the setting of the conditions for a method for measuring the inhibitory activity of a compound against EGFR kinase activity in vitro, ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...More data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
University of Kalmar

LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP0531US Patent
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
University of Kalmar

LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP0531US Patent
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
University of Kalmar

LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP0531US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM1773(US10280174, Comparative Compound 1 | US8476284, 4 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair