null

SMILES CC(C)C(=O)N1CCC(CC1)c1cn(C)c2ncc(NC(=O)c3cccc(c3)C#N)c(c12)C(F)(F)F

InChI Key InChIKey=BIHPJIJLDNUDGH-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 189877   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)copy SMILEScopy InChI
Affinity DataIC50: 17nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28G8HWTUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)copy SMILEScopy InChI
Affinity DataIC50: 16.6nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2ZGVUS Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)copy SMILEScopy InChI
Affinity DataIC50: 16.6nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9M91US Patent
TargetNuclear receptor ROR-gamma(Mus musculus)
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at RORC2 in BALB/c mouse Th17 cells assessed as inhibition of IL17A production after 4 days by electrochemiluminescence assa...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)copy SMILEScopy InChI
Affinity DataIC50: 9.5nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)copy SMILEScopy InChI
Affinity DataIC50: 16.6nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25QBUS Patent