null

SMILES CN(C)C\C=C\C(=O)N1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=KAKJQMPMDALLHT-RMKNXTFCSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 191612   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM191612(US9181263, 7 | US9278100, 7)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM191612(US9181263, 7 | US9278100, 7)copy SMILEScopy InChI
Affinity DataIC50: 6.12E+3nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM191612(US9181263, 7 | US9278100, 7)copy SMILEScopy InChI
Affinity DataIC50: 269nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM191612(US9181263, 7 | US9278100, 7)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM191612(US9181263, 7 | US9278100, 7)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM191612(US9181263, 7 | US9278100, 7)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM191612(US9181263, 7 | US9278100, 7)copy SMILEScopy InChI
Affinity DataIC50: 6.12E+3nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM191612(US9181263, 7 | US9278100, 7)copy SMILEScopy InChI
Affinity DataIC50: 269nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
PHARMACYCLICS LLC

US Patent
LigandPNGBDBM191612(US9181263, 7 | US9278100, 7)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM191612(US9181263, 7 | US9278100, 7)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent