null
SMILES COC1CCC2(Cc3ccc(cc3C22N=C(N)N(C(C)C)C2=O)C#N)CC1
InChI Key InChIKey=HXYCKOWFLDTBJS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 195494
Affinity DataIC50: 107nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
TargetBeta-secretase 1 [1-458](Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
US Patent
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
US Patent
Affinity DataIC50: 49.3nMpH: 4.4Assay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair