null
SMILES Oc1cccc(CNC(=O)Nc2nc(cs2)-c2ccncc2)c1
InChI Key InChIKey=GDVRVPIXWXOKQO-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 31 hits for monomerid = 199250
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
Affinity DataIC50: 8nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
Affinity DataIC50: 9nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
Affinity DataIC50: 6nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
Affinity DataIC50: 8nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
Affinity DataIC50: 6nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal GST-tagged ROCK1 (1 to 535) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of MLCK1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal GST-tagged ROCK2 (1 to 552) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
Affinity DataIC50: 0.530nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of LIMK1 (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of SGK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+5nMAssay Description:Inhibition of CK1-alpha1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of DMPK (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of MRCKalpha (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PKN1 (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of Aurora-A (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
Affinity DataIC50: 0.450nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of p70S6K (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of TBK1 (unknown origin)More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of IKKepsilon (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of ACK1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
In DepthDetails
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
H. Lee Moffitt Cancer Center and Research Institute, Inc.
US Patent
Affinity DataIC50: 13nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair