null

SMILES O=c1[nH]nc2CCCc3[nH]c4cccc1c4c23

InChI Key InChIKey=GGJVOTFHPYZESL-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 207556   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3KBDUS Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474FGFPubMed
TargetIsoform 2 of Protein mono-ADP-ribosyltransferase PARP3 (Long)(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 199nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3KBDUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3KBDUS Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CN75ZVUS Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CN75ZVUS Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.99E+5nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CN75ZVUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+5nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CN75ZVUS Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89FS5US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89FS5US Patent
TargetProtein mono-ADP-ribosyltransferase PARP3(Homo sapiens (Human))
BEIGENE, LTD.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.99E+5nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89FS5US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+5nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89FS5US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 6.70E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89FS5US Patent
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89FS5US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.54E+5nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89FS5US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataEC50:  3.60nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474FGFPubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474FGFPubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207556(US10501467, Example 2 | US9260440, 1 | US9617273, ...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3KBDUS Patent