null

SMILES CC1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O

InChI Key InChIKey=GVENJEQXWSQXEC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 207573   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207573(US10501467, Example 18 | US9260440, 18 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3KBDUS Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207573(US10501467, Example 18 | US9260440, 18 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CN75ZVUS Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207573(US10501467, Example 18 | US9260440, 18 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474FGFPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207573(US10501467, Example 18 | US9260440, 18 | US9617273...)copy SMILEScopy InChI
Affinity DataEC50:  2.70nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474FGFPubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM207573(US10501467, Example 18 | US9260440, 18 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474FGFPubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
BeiGene, Ltd.

US Patent
LigandPNGBDBM207573(US10501467, Example 18 | US9260440, 18 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89FS5US Patent