null

SMILES C[C@@H]1CN(CCN1C(=O)Nc1nc2ccc(F)cc2s1)c1ncc(cc1F)[C@@H](O)CO

InChI Key InChIKey=GWEKEPTYZIALJB-BZNIZROVSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 210896   

TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent
LigandPNGBDBM210896(US9273043, A125(e))copy SMILEScopy InChI
Affinity DataIC50: 23.9nMpH: 7.4Assay Description:One day prior to assay, TRPV1/CHO cells were seeded in 96-well clear-bottom black plates (20,000 cells/well) in growth media. On the day of the exper...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2D7998GUS Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent
LigandPNGBDBM210896(US9273043, A125(e))copy SMILEScopy InChI
Affinity DataIC50: 18.4nMT: 2°CAssay Description:Briefly, hTRPV1/CHO cells were cultured in growth media in a tissue culture dish at 37° C. in a CO2 incubator. On the day of the assay, culture m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2D7998GUS Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent
LigandPNGBDBM210896(US9273043, A125(e))copy SMILEScopy InChI
Affinity DataIC50: 0.600nMpH: 7.2 T: 2°CAssay Description:pH dependent Ca2+ responses in TRPV1/CHO cells cultured in a 96-well plate were determined (see, e.g., FIG. 2 of U.S. Patent Application Publication ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2D7998GUS Patent