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SMILES Cn1cc(-c2cc(ccc2Oc2ccccc2)S(C)(=O)=O)c2cc[nH]c2c1=O

InChI Key InChIKey=CGASLGCHTWREOZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 220496   

TargetBromodomain-containing protein 4 [352-457](Homo sapiens (Human))
AbbVie Inc.

US Patent
LigandPNGBDBM220496(US9296741, 85)copy SMILEScopy InChI
Affinity DataKi:  1.70nM ΔG°:  -12.0kcal/molepH: 6.0 T: 2°CAssay Description:A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26W98ZQUS Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM220496(US9296741, 85)copy SMILEScopy InChI
Affinity DataKi:  5.80nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251MB8PubMed
TargetBromodomain-containing protein 4 [57-168](Homo sapiens (Human))
AbbVie Inc.

US Patent
LigandPNGBDBM220496(US9296741, 85)copy SMILEScopy InChI
Affinity DataKi:  6.40nM ΔG°:  -11.2kcal/molepH: 6.0 T: 2°CAssay Description:A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26W98ZQUS Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
AbbVie Inc.

Curated by ChEMBL
LigandPNGBDBM220496(US9296741, 85)copy SMILEScopy InChI
Affinity DataEC50:  50nMAssay Description:Inhibition of BRD4 in human H1299 cells assessed as decrease in HPV LCR-E2-EP400-mediated transcriptional repression after 24 hrs by Bright-Glo lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251MB8PubMed