null
SMILES Cc1nnc2[C@H](CC(=O)N\N=C\c3ncc[nH]3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 223491
TargetBromodomain-containing protein 4(Homo sapiens (Human))
DANA-FARBER CANCER INSTITUTE, INC.
US Patent
DANA-FARBER CANCER INSTITUTE, INC.
US Patent
Affinity DataIC50: 3.48nMpH: 7.4 T: 2°CAssay Description:BRD4(1): Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents wer...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
DANA-FARBER CANCER INSTITUTE, INC.
US Patent
DANA-FARBER CANCER INSTITUTE, INC.
US Patent
Affinity DataIC50: 0.240nMpH: 7.4 T: 2°CAssay Description:BRD4(2): Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents wer...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Tensha Therapeutics, Inc.
US Patent
Tensha Therapeutics, Inc.
US Patent
Affinity DataIC50: 0.240nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Dana-Farber Cancer Institute, Inc.
US Patent
Dana-Farber Cancer Institute, Inc.
US Patent
Affinity DataIC50: 0.240nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Tensha Therapeutics, Inc.
US Patent
Tensha Therapeutics, Inc.
US Patent
Affinity DataIC50: 3.48nMAssay Description:The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Dana-Farber Cancer Institute, Inc.
US Patent
Dana-Farber Cancer Institute, Inc.
US Patent
Affinity DataIC50: 3.48nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair