null

SMILES O=C1N=C(NC23CC4CC2CC(C3)C4)SC11CCCC1

InChI Key InChIKey=GXHSOLWRHSMNFU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 22473   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Biovitrum AB

LigandPNGBDBM22473(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)copy SMILEScopy InChI
Affinity DataKi:  3nM ΔG°:  -11.5kcal/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56Q8PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Biovitrum AB

LigandPNGBDBM22473(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)copy SMILEScopy InChI
Affinity DataKi:  120nM ΔG°:  -9.34kcal/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant enzymes, incubating with test compound and [3H]cortisone/NADPH. After incubation, the amount ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56Q8PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Biovitrum AB

LigandPNGBDBM22473(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)copy SMILEScopy InChI
Affinity DataKi:  180nM ΔG°:  -9.10kcal/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant enzymes, incubating with test compound and [3H]cortisone/NADPH. After incubation, the amount ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56Q8PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Biovitrum AB

LigandPNGBDBM22473(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:The assay was performed at room temperature in a 96-well microtiter plate containing substrate mixture [3H]cortisol/NAD+, inhibitors, and 11beta-HSD2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56Q8PubMed