null
SMILES CC[C@]1(O)C[C@H]2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
InChI Key InChIKey=JXLYSJRDGCGARV-XQKSVPLYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 227643
Affinity DataIC50: 1.75E+4nMT: 2°CAssay Description:For the data shown, 25 nM BD-verapamil was added to various P-gp nanodisc concentrations in the presence of 1 μM empty nanodiscs, and 50 nM BD-v...More data for this Ligand-Target Pair
Affinity DataIC50: 8.80E+3nMT: 2°CAssay Description:For the data shown, 25 nM BD-verapamil was added to various P-gp nanodisc concentrations in the presence of 1 μM empty nanodiscs, and 50 nM BD-v...More data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of chymotrypsin-like activity of human 26S proteasome using Suc-LLVY-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of trypsin-like activity of human 26S proteasome using Boc-LRR-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of PGPH activity of human 26S proteasome using Z-LLE-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Affinity DataIC50: 4.28E+3nMAssay Description:Inhibition of PGPH activity of human 20S proteasome using Z-LLE-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasome using Boc-LRR-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Nagahama Institute of Bio-Science and Technology
Curated by ChEMBL
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.51E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair