null

SMILES Nc1cc(c(cn1)-c1nc2N3CCOC[C@@H]3Cc2c(n1)N1CCOCC1)C(F)(F)F

InChI Key InChIKey=VEUJAZRDHNBJQE-NSHDSACASA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 228153   

LigandPNGBDBM228153((S)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human full-length N-terminal His6-tagged p110alpha/p85alpha expressed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5JW1PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University of Basel

Curated by ChEMBL
LigandPNGBDBM228153((S)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 751nMAssay Description:Inhibition of mTORC1 in human A2058 cells assessed as reduction in ribosomal protein S6 phosphorylation at Ser235/236 residues incubated for 1 hr by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5JW1PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
University of Basel

Curated by ChEMBL
LigandPNGBDBM228153((S)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 353nMAssay Description:Inhibition of mTORC2 in human A2058 cells assessed as reduction in PKB phosphorylation at S473 residues incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5JW1PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
SUNSHINE LAKE PHARMA CO., LTD.

US Patent
LigandPNGBDBM228153((S)-5-(4-morpholino-5a,6,8,9-tetrahydro-5H- pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 98.1nMpH: 7.5Assay Description:N-terminally His-tagged PI3K alpha (Cat. No. PV4789; 0.49 mg/ml), Alexa FluorŪ 647 labeled kinase Tracer 314 (Cat. No. PV6087), Biotin anti-His Tag a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22R3TPVUS Patent