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SMILES Cc1ccc(Cl)c(Nc2ccccc2C(=O)NCCOc2ccccc2)c1Cl

InChI Key InChIKey=CBUNQTSLJBKXPU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 22975   

TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School of Medicine

LigandPNGBDBM22975(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)copy SMILEScopy InChI
Affinity DataIC50: 6.60E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP736GPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University School of Medicine

LigandPNGBDBM22975(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)copy SMILEScopy InChI
Affinity DataIC50: 150nMT: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test compounds for 20 min and then analyzed for remaining COX activity by tr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP736GPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School of Medicine

LigandPNGBDBM22975(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)copy SMILEScopy InChI
Affinity DataIC50: 400nMT: 2°CAssay Description:Inhibition assays in triplicate were performed by preincubating enzyme (60-80 nM) and inhibitors (0-5 mM) for 20 min at 25°C followed by the add...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP736GPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University School of Medicine

LigandPNGBDBM22975(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)copy SMILEScopy InChI
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of the human Prostaglandin G/H synthase 2 was determined by thin-layer chromatography assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP0247PubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt University School of Medicine

LigandPNGBDBM22975(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP0247PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School of Medicine

LigandPNGBDBM22975(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibition of the wild type murine Prostaglandin G/H synthase 2 wildtype enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP0247PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Vanderbilt University School of Medicine

LigandPNGBDBM22975(2-[(2,6-dichloro-3-methylphenyl)amino]-N-(2-phenox...)copy SMILEScopy InChI
Affinity DataIC50: 550nMAssay Description:Inhibition of the Arg120Ala murine COX-2 mutant enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BP0247PubMed