null
SMILES OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(O)CCC1
InChI Key InChIKey=FHQXLWCFSUSXBF-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 237920
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataEC50: 4.20nMpH: 7.5 T: 2°CAssay Description:The biochemical EC50 (half-maximal concentration required for full activation) of compounds for the activation of AMPK was evaluated by 33P-based ass...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-2/subunit gamma-1(Rattus norvegicus)
Terns Pharmaceuticals
Curated by ChEMBL
Terns Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of rat hepatocytes AMPK alpha1/beta2/gamma1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataEC50: 7nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit gamma-1(Rattus norvegicus)
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataEC50: 7nMAssay Description:Activation of recombinant rat AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphorylat...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of recombinant human AMPK alpha2/beta2/gamma1 using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataEC50: 8.20nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 assessed as protection from Thr172 residue dephosphorylation preincubated for 15 mins follow...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataEC50: 3.30nMAssay Description:Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataEC50: 28nMAssay Description:Activation of recombinant human BAP-tagged AMPK alpha1/beta1/gamma1 assessed as protection from Thr172 residue dephosphorylation preincubated for 15 ...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-2/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of recombinant human AMPK alpha1/beta2/gamma1 using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataEC50: 6.80nMAssay Description:Activation of recombinant human AMPK alpha2/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphoryl...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit beta-2(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of recombinant human AMPK alpha2/beta2/gamma3 by using Cy5-labelled SAMS as substrate in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataKd: 9nMAssay Description:Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human recombinant 5-HT2b receptor expressed in CHO cells measured after 30 mins by HTRF assayMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataKd: 9nMAssay Description:Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assayMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataEC50: 5.60nMAssay Description:Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assayMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit beta-2(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of full-length recombinant N-terminal His-tagged human AMPKalpha2beta2gamma3 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of full-length recombinant N-terminal His-tagged human AMPKalpha2beta2gamma1 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataKd: 9nMAssay Description:Binding affinity to Bap-tagged human AMPKalpha1beta1gamma1 expressed in Escherichia coli BL21 cells by SPR analysisMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit beta-1(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Activation of recombinant AMPKbeta1 in cryopreserved human hepatocytes assessed as reduction in 14C-2-acetic acid incorporation after 1 hr by scintil...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-2/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataEC50: >4.00E+4nMAssay Description:Activation of full-length recombinant N-terminal His-tagged human AMPKalpha1beta2gamma1 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataEC50: 1.90nMAssay Description:Activation of full-length recombinant N-terminal His-tagged human AMPKalpha1beta1gamma1 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Activation of full-length recombinant N-terminal His-tagged human AMPKalpha2beta1gamma1 expressed in Escherichia coli BL21 cells using Cy-5 SAMS pept...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Pfizer Inc.
US Patent
Pfizer Inc.
US Patent
Affinity DataEC50: 4.20nMAssay Description:Activation of full length human phosphorylated His-tagged AMPK alpha1/beta1/gamma1 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL using SAMS...More data for this Ligand-Target Pair