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SMILES NC1CCc2ccccc2C1

InChI Key InChIKey=LCGFVWKNXLRFIF-UHFFFAOYSA-N

PDB links: 4 PDB IDs contain this monomer as substructures. 4 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 23981   

TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
University of Kansas

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataKi:  6.80E+3nMAssay Description:In vitro inhibitory activity against bovine phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P55P32PubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataKi:  1.11E+4nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortical membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25KJPubMed
TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
University of Kansas

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of Phenylethylamine N-Methyltransferase (PNMT) using radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H41S10PubMed
TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
University of Kansas

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of phenylethanolamine N-methyl-transferase (PNMT)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4R6NPubMed
TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
University of Kansas

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity of the compound to phenylethanolamine N-methyltransferase(PNMT) in bovineMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23J3BZWPubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataKi:  3.98E+4nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3TM8PubMed
TargetBacterial leucyl aminopeptidase(Vibrio proteolyticus)
ENSCMu

LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29V73PubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XW4KB0PubMed
TargetCytosol aminopeptidase(Bos taurus (bovine))
ENSCMu

LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMpH: 8.0 T: 2°CAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29V73PubMed
Target5-hydroxytryptamine receptor 2B(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataKd:  2.45E+3nMAssay Description:The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2902507PubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
ENSCMu

LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29V73PubMed
TargetAminopeptidase N(Sus scrofa (Pig))
ENSCMu

LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29V73PubMed