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SMILES Cc1cc(Nc2ccc3ccccc3c2)n2ncnc2n1

InChI Key InChIKey=WPVMVODGPNYYEV-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 24400   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas Southwestern Medical Center at Dallas

LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 47nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas Southwestern Medical Center at Dallas

LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 47nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei)
University of Washington at Seattle

LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human DHODH expressed in Escherichia coli by DCIP staining-based spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2988BJHPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
State Key Laboratory of Bioreactor Engineering

Curated by ChEMBL
LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of Plasmodium falciparum DHODH (Phe158 to Ser569) expressed in Escherichia coli BL21 using dihydroorotate as substrate measured every 30 s...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas Southwestern Medical Center at Dallas

LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Inhibition of Plasmodium falciparum recombinant N-terminal His6-tagged DHODH (159-569 residues) expressed in Escherichia coli BL21(DE3) using DHO as ...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395](Homo sapiens (Human))
University of Washington at Seattle

LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed