null

SMILES CCn1c(nc2cncc(C(=O)N3CC[C@@H](N)C3)c12)-c1nonc1N

InChI Key InChIKey=PHWHNHYZZNJPLB-MRVPVSSYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 24991   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24991(4-(7-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-1-eth...)copy SMILEScopy InChI
Affinity DataIC50: 331nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24991(4-(7-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-1-eth...)copy SMILEScopy InChI
Affinity DataIC50: 2.34E+3nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24991(4-(7-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-1-eth...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24991(4-(7-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-1-eth...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM24991(4-(7-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-1-eth...)copy SMILEScopy InChI
Affinity DataIC50: 1.29E+3nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5K3HPubMed